Flmodafinil (CAS No. 90280-13-0) also known as bisfluoromodafinil, lauflumide, CRL-40,940, N-deshydroxyl Fladrafinil and bis-(p)-fluoromodafinil is a new medicine which promises advantages over Modafinil. Its structure is almost identical to Modafinil with addition of just two fluoride atoms. This small change in structure has led to increased effectiveness by almost four times, longer duration of action as well as minimal adverse effects as compared to Modafinil. Similar to Modafinil, it is also used as wakefulness-enhancing agent in conditions leading to excessive daytime sleepiness. Since it is fairly a new drug, so, it is being studied in clinical trials for its use in narcolepsy and other sleep disorders. There are some potential benefits observed with Flmodafinil like increasing attentiveness in subjects with fatigue and counteracting harmful effects related to sleep deprivation, may also improve learning skills and recall in healthy as well as patients dealing with depression. Some evidence from the animal studies have shown that Flomodafinil can be used as mood booster and can help in increasing concentration in heathy or sleep deprived subjects.

Bromantane Being bisfluoro analogue of modafinil, its mechanism of action is similar to modafinil and acts by inhibiting the reuptake of dopamine leading to increased concentration of dopamine. It should be started at fairly low dose of 12.5mg to 25mg in beginners and around 100mg for not more than 2-3 times in a week in subjects who have already taken Modafinil in the past. Dose of 150mg or more is generally nor recommended as it may lead to side effect of insomnia but some users use it to stay awake all night.

Because of the fact that it is relatively a new medicine and still undergoing several clinical trials, its spectrum of adverse events is not well known, but it has been claimed that this medicine will have fewer and milder adverse events as compared to Modafinil. This notion has been backed up by anecdotal reports obtained from subjects who took both Modafinil and Flomodafinil as part of the research. Also, keeping in structure similarity of Flomodafinil and Modafinil, their range of side effects would be quite similar like headache, anxiety, gastrointestinal issues.


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