Chemical Products 2-Amino-5-bromopyridine Description

Chemical Products 2-Amino-5-bromopyridine Description
Light yellow Cryst

Chemical Products 2-Amino-5-bromopyridine Basic Attributes
CAS No:1072-97-5

Molecular Formula :C5H5BrN2

Molecular Mass :173.01

Exact Mass :171.963608

PSA :38.9 A^2

LogP :1.2

EINECS :214-019-9


H-bond Acceptor :2

H-bond Donor :1

SP3 :0.00

RBN :0

Chemical Products 2-Amino-5-bromopyridine Characteristics
Appearance :White to beige Crystalline Powder

Density :1.6065 (rough estimate)

Melting Point :133-138 °C(lit.)

Bolling Point :230.9±20.0 °C(Predicted)

Flash Point :93.4±21.8 °C

Refractive Index :1.5182 (estimate)

Solubility :Soluble in methanol, chloroform, ethyl acetate. Slightly soluble in water.

Storage Condition :Store below +30°C.

BRN :108737

Chemical Products 2-Amino-5-bromopyridine Safety Information
Hazard Class :IRRITANT

HS Code :29333999

UN No. :UN 2811 6.1/PG 3

WGK_Germany :2

Risk Code :22-36/37/38

Safety Instructions :26-36

Dangerous Mark :Xn,Xi

P Code :P261-P301 + P310-P305 + P351 + P338

Hazard Statements :H301-H315-H319-H335

Hazard Note :Irritant

Chemical Products 2-Amino-5-bromopyridine Product Usage
2-Amino-5-bromopyridine is an organic synthesis intermediate and pharmaceutical intermediate. It can be used in the laboratory research and development process and the chemical medicine research and development process. It can be used as a raw material for the preparation of drugs and fine chemicals.

Chemical Products 2-Amino-5-bromopyridine Material and Products
Products :
2-AMINO-5-BROMO-3-IODOPYRIDINE, 2-Amino-5-bromo-3-nitropyridine, 6-BROMO-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE, 2-Fluoropyridine-5-carboxaldehyde, 5-Bromo-2-chloro-3-nitropyridine, 2-Amino-3,5-dibromopyridine, 5-P-TOLYLPYRIDIN-2-YLAMINE, 2-AMINO-5-PHENYLPYRIDINE, 2-Amino-5-cyanopyridine, 5-Bromo-3-nitro-2-pyridinol, 6-BROMO-2-METHYLIMIDAZO[1,2-A]PYRIDINE, 3-AMINO-5-BROMO-PYRIDIN-2-OL, 2-Hydroxy-5-bromopyridine, 2-Hydroxy-3-amino-5-bromopyridine, 1,1′-Biphenyl, 2-AMINO-3-CHLORO-5-BROMOPYRIDINE, 2-Fluoro-5-bromopyridine

Chemical Products 2-Amino-5-bromopyridine Production Methods
General procedure: Nitrobenzene (0.6mmol), 5wtpercent Pd/C (0.5mmol percent, 0.003mmol), H2O (10 equiv, 6.0mmol), B2(OH)4 (3.3 equiv, 2.0mmol), and CH3CN (1.0mL) were added in a 10mL tube. The reaction mixture was stirred at 50°C for 24h. When the reaction was complete monitored by TLC, the mixture was cooled to room temperature. Water (5mL) was added, and extracted with EtOAc (3×5mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give aniline 2a (55mg, 99percent).To the mixture of pyridin-2-ylamine (10.0 g, 106 mmol) in acetone (200 mL), was added NBS (22.6 g, 127 mmol) portionwise at 0°C. The mixture was warmed to room temperature and stirred overnight. Solvent was evaporated in vacuum. The residue was purified by silica gel column (DCM/MeOH, 20/1) to afford 18 g (yield: 98percent) of 5-bromo-pyridin-2- ylamine as yellow solid. [00589] 1H NMR (DMSO-d6): δ = 7.94 (IH, d), 7.61 (IH, dd), 6.43 (IH, d), 6.10 (2H, brs).4.5.4 14.8 g (89.4 mmol) of potassium bromate was dissolved in the succinimide aqueous solution recovered in the previous step.In the condition of 25 °C, stirring, 17.5 mL of 50percent sulfuric acid aqueous solution was added dropwise.

Comments are closed