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Deferiprone is an FDA-approved drug used to treat transfusion-dependent thalassemia and a variety of other disorders. Dr. Kontoghiorghes synthesized deferiprone, a type of hydroxypyridinone iron chelator, in the early mid-1980s. Iron is required for the survival of nearly all species. When the body experiences primary iron overload (hemochromatosis) or secondary iron overload (transfusion-dependent thalassemia), a massive accumulation of potentially toxic substances occurs, followed by iron-induced early death. The iron chelator is bound to ferric ions (iron III) in the drug, forming a stable complex that is then eliminated in the urine.

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